UptownPicked by: Chef James Scott Cullen of Press Street Station "My favorite po-boy is a fried oyster, dressed, from Domilise's. It was the first thing I ever ate in New Orleans. The backstory to this is I met my wife over an argument about French bread in Hoboken, New Jersey. I always thought French bread was a baguette. She taught me by taking me to Domilise's on my first trip here in 2010. So for sentimental reasons, this is my answer. I probably like the shrimp at Zimmer's as my absolute fave as far as quality goes, or maybe the roast beef at R & O's. They both use Gendusa bread, which I love.

This place is such a cult favorite that it sells branded T-shirts and beer-can coolers as merchandise. Today, this 1918-founded establishment is run by the fourth generation of the Domilise family. The quaint wooden dining room is trimmed with black-and-white photos, vintage hot-sauce posters and signed football snaps, but you’ll likely have to queue before you get inside.

Domilise’s is the po’boy shop equivalent of your cooler, older friend’s house. You know, the one that’s full of joyful relics that remind you of the good ol’ days. The menu here is handwritten, the tables are all laminated, and awards and photos of customers and employees fill the walls.

What is it: A beloved neighborhood dive, Domilise’s is the favorite of generations of New Orleanians. Why we love it: Step back in time and grab a seat at a formica table to enjoy a good dose of history and camaraderie alongside your po’boy. And the po’boys are well worth any wait.

Situated in a modest, mellow yellow house, Domilise's humble exterior belies a legacy that may seem unbelievable to an outsider. Since 1918, the sandwich icon has provided some of New Orleans' best-loved po'boys to everyone, from local passers-by to hungry tourists to notable politicians and celebrities. The restaurant cultivates a family-friendly environment and reflects such values itself: Many of its staff members have worked at Domilise's for decades, and while the years have flown by, the recipes behind the simple menu remain largely unchanged.

If there’s one food you simply must try when exploring New Orleans, it’s the city’s signature sandwich, the mouth-wateringly delicious po’ boy. The Big Easy’s answer to the Philadelphia cheesesteak or the Chicago hot dog, few meals in New Orleans surpass the simple charm of deep-fried seafood stuffed into a crunchy French baguette. While there are many New Orleans restaurants that feature po’ boys on their menu, Domilise’s might just take rank as the very best po’ boy sandwich shop in the city.

In a city where it seems there are as many po'boy joints as people, Domilise's stands apart. The cottony French bread is from Leidenheimer, the iconic local bakery; the catfish, shrimp, and oysters are freshly fried; and the proprietors are adept practitioners of New Orleans–style gruff love. There's even a strange ritual that involves standing in line to obtain a number that grants you the privilege of standing in another line to order.

The Northeast has the sub, Philly has the hoagie, and the New Orleans’s beloved sandwich mascot is the po’boy. And Domilise’s, which celebrated its one hundredth anniversary last year, is the place to try the best. It’s not fancy (the wood-paneled walls and the red and yellow plastic bottles of ketchup and mustard on Formica tables are delightfully retro), but the food is heavenly.

If you want a po-boy from which all other po-boys will be measured, stop by Domilise’s Po-boys & Bar in the city’s Uptown neighborhood. Here you’ll find Louisiana sandwiches made with fresh ingredients and genuine care. A cold beer and shrimp po-boy is a great combination when you’re at the bar, or take a seat outside and savor a hot smoked sausage sandwich as you people watch.

One of the few storefronts to survive the tragedy of Hurricane Katrina, this Po’ Boy shop and bar still stands where it has been operating for nearly a century. DomiLise’s offers all the classic Po’ Boy fillings, shrimp, roast beef, and oysters. Tony tries the “off-the-menu special,” which is a Po’ boy consisting of deep-fried shrimp, Swiss cheese, and roast beef gravy.

» For a true local scene, head to Domilise’s in the early afternoon: It’s as much theater as it is lunch. The family of matriarch Dot Domilise (who is mostly retired these days) slices the bread for the po’boys to order in a kitchen about the size of a backyard hot tub. A line often snakes between the tables of the cramped interior, once a barroom.

A nondescript frame building in which the most fabulous po-Boys in New Orleans are prepared. It features a wide range of sandwiches, but for me it is impossible not to gravitate toward fried seafood po-boys, fried and made to order, fully dressed. While many locals go with a Barq’s as an accompaniment; it’s an Abita Amber for me.

Family owned and operated for over a century, and the winner of the Travel Channel’s Food War’s competition for best shrimp po-boy, Domilise’s Po-Boy & Bar is an Uptown gem. While every item on their menu is delicious, locals will recommend their fried oyster, fried shrimp, or roast beef po-boy. Can’t decide between them?

The next morning, we ventured further out to the Uptown area of the city to check out Domilise’s Po-Boy & Bar. Michael, the concierge at the Hilton Riverside, who was our inside source of restaurant information, said that while it was a neat place to check out, the po’ boys were just ok. His assessment was pretty spot-on.

Mother’s typically has a line around the corner, and Stanley does a more high-end version of this NOLA staple. However, Domilise’s holds a special place in the hearts of many. Open since 1918, this no-frills shop serves excellent shrimp, oyster, roast beef, and sausage po-boys on fresh, crispy Leidenheimer bread.

A local institution since 1924, Domilise’s is a no-frills spot a few blocks from the Mississippi River. It’s been owned by the Domilise family, who lived in the house above the restaurant, for over 75 years. Upon entering, you’ll be asked to take a number that will be called when they’re ready for you to order.

Domilise's is a long-standing po-boy restaurant that serves sandwiches only. Their history and focus on po-boys seem to be part of the reason their sandwiches are so beloved. Large fried gulf oysters fill crispy Leidenheimer bread along with fresh lettuce and a healthy dose of mayo and ketchup.

Domilise’s was founded in 1918 and if you do not mind waiting in a line for a little bit while enjoying the Garden district, Get yourself a Fried Oyster po Boy from Domilise’s. The secret is out and even though this place is still full of locals many tourists have found this gem.

It’s been open for 100 years and its classic fried shrimp or roast beef po’ boys have a cult following among locals. No frills and much beloved, your best bet is to avoid Tuesdays and Thursdays when the line is extra long as Tulane students get a discount.

Domilise's, a hidden Uptown dive, reflects a homecooked neighborhood bar—It's like a garage bar in somebody's grandmother's house. Order This: Oyster Po'boy. Enjoy a simple presentation of a lowbrow Louisiana seafood classic with a squirt of ketchup.

- Rating: 4.5 / 5 (396 reviews)- Detailed ratings: Food (4.5/5), Service (4.0/5), Value (4.0/5), Atmosphere (3.5/5)- Type of cuisine: Quick Bites, American- Address: 5240 Annunciation St, New Orleans, LA 70115-1848- Read more on Tripadvisor

A fluffy french bread loaf overflowing with fried seafood or meat, and dressed with shredded lettuce, tomato, and mayo. If you’re looking for a true classic, get yourself a fried shrimp po-boy from this near 100 year-old establishment.

Shrimp or oyster is the classic choice best procured from Domilise’s, Guy’s or Parkway Tavern, but places like Killer PoBoys and Crabby Jack’s have more unusual and modern offerings like duck or pork belly.

5240 Annunciation StNew Orleans, LA 70115 +1 504 899 9126 Visit Website See Menu Open in Google Maps. Domilise’s Po-Boy & Bar is a longtime-running local institution and sandwich shop dating back to 1924.

5240 Annunciation St, New Orleans, LA 70115Phone: 504-899-9126 Visit Website. View this post on Instagram. A post shared by Domilises Poboys (@domilisespoboys)

5240 Annunciation St, New Orleans, LA 70115 | (504) 899-9126. Here’s what one reviewer says about Domilie’s: “Great little place. Classic NOLA po-boys.

Don’t let Domilise’s appearance mislead you, the quaint restaurant, inside a little yellow house, offers a delicious must-have po’ boy.